TREATMENT RESISTANT DEPRESSION
Patricio Riva Posse, MD | Emory
Cheryl McCullumsmith, MD, PhD | University of Cincinnati
In the current era of ‘precision medicine’ we are far better placed than ever before to resolve these important issues. Towards this, our Task Group, together with the NNDC Biomarkers Task Group, is embarking on a collaborative project specifically aimed at identifying why some patients respond to a specific treatment, while others do not. By combining our expertise, resources and treatment trials across Centers within the Network, we are optimally placed to identify and develop biomarkers that can be used to individualize treatment plans for our patients – helping to get the best therapy to each individual patient faster and avoid the current (mostly) ‘trial and error’ process.
RESEARCH & BACKGROUND
Depression is a chronic and severe psychiatric illness that affects over 15 million people in the United States and by 2020 is expected to be the leading cause of disability worldwide. Unfortunately, up to a third of patients do not respond to currently available treatments, and are considered to have treatment-resistant depression (TRD). Compared with treatment-responsive depression, TRD is associated with a more chronic and severe illness course, progressively detrimental effects on brain structure and functioning, increased healthcare costs, and risk of premature death by medical illnesses and suicide. As we better understand the medical underpinnings of depressive illness, we are increasingly appreciating that treatment-resistant forms of this illness have a distinct pathology from treatment-responsive forms. Our Task Group is actively involved in development of treatment, research and educational strategies aimed at helping to understand these differences, close the gap on non-response and personalize treatments for TRD.
ABCB1 (MDR1) predicts remission on P-gp substrates in chronic depression. Ray A, Tennakoon L, Keller J, Sarginson JE, Ryan HS, Murphy GM, Lazzeroni LC, Trivedi MH, Kocsis JH, DeBattista C, Schatzberg AF.
A Randomized Sham-Controlled Trial of Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Chronic Treatment-Resistant Depression.
Dougherty DD, et al. Biol Psychiatry. 2014.
Davis J, Maes M, Andreazza A, McGrath J, Tye SJ, Berk M. Towards a classification of biomarkers of neuropsychiatric disease: From encompass to compass. Mol Psychiatry. 2015 Feb;20(2):152-3.
Frye MA, Prieto ML,. Bobo WV, Kung S, Veldic M, Alarcon RD, Moore KM, Choi DS, Biernacka JM, Tye SJ. Current landscape and unmet needs for treatment of bipolar depression. Journal of Affective Disorders. 2014 Dec;169 Suppl 1:S17-23.
Frye MA, Blier P, Tye SJ. Concomitant Benzodiazepine Use Attenuates Ketamine Response: Implications for Large Scale Study Design and Clinical Development. J. Clin. Psychopharmacol. 2015 Jun;35(3):334-6
Haq AU, Sitzmann AF, Goldman ML, Maixner DF, Mickey BJ. 2015. Response of Depression to Electroconvulsive Therapy: A Meta-Analysis of Clinical Predictors. Journal of Clinical Psychiatry, in press.
Riva-Posse P, Hermida AP, McDonald WM. The role of electroconvulsive and neuromodulation therapies in the treatment of geriatric depression, Psychiatr Clin N Amer 36 2013 Dec. 607-30.
Walker AJ, Burnett SA, Hasebe K, Gray L, McGee SL, Walder K, McGillivray J, Berk M, Tye SJ (2013) Chronic adrenocorticotrophic hormone treatment alters tricyclic antidepressant efficacy and prefrontal monoamine tissue levels.Behavioural Brain Research. 242:76–83