Six Loci Linked to Personality Traits in Meta-Analysis
Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders
A team led by the University of California, San Diego’s Chi-Hua Chen conducted a meta-analysis of genome-wide association studies that examined personality traits. Under the five-factor model of personality, there are five personality dimensions: extroversion, neuroticism, agreeableness, openness, and conscientiousness. Previous work, the researchers noted, has indicated that about 40 percent of variance in personality may be genetic.
As Chen and her colleagues reported in Nature Genetics today, they linked six genetic loci to these personality traits and examined their genetic ties to a handful of psychiatric disorders.