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MOOD OUTCOMES PROGRAM

Transforming Mood Disorders Care Through Measurement-Based Practice

The NNDC Mood Outcomes Program helps leading mental health centers improve patient outcomes, standardize measurement-based care, and advance collaborative research through a national network of clinicians, researchers, and health systems.

Using real-time patient-reported outcomes, clinical decision support tools, and a growing national outcomes repository, participating centers are helping shape the future of depression and bipolar disorder care.

Why It Matters

Mood disorders remain among the leading causes of disability worldwide, yet care is often delivered without standardized outcomes tracking. The Mood Outcomes Program helps bridge that gap by providing participating centers with practical tools to measure patient progress, improve care delivery, and contribute to a larger effort to advance the treatment of mood disorders.

Only NNDC Members may access the data using the Data Request form link below under the resources section.

Impact at a Glance
  • 16 Participating NNDC Member Centers
  • Growing National Repository of Patient Outcomes Data Managed by Johns Hopkins University
  • 140,000+ Unique Patients Enrolled
  • Longitudinal Data Ranging Back to 2014
  • Several Scholarly MOP Publications and Presentations
  • Standardized Measurement-Based Care Across Multiple Health Systems
  • National Network of Academic Medical Centers, Specialty Behavioral Health Providers, and Research Institutions
  • Real-Time Clinical Reporting and Decision Support Tools
  • Supporting Multi-Site Research, Quality Improvement, and Innovation
Resources
Participating Centers

The Mood Outcomes Program continues to expand across the NNDC network, with member centers contributing data to the repository and additional sites at various stages of implementation and onboarding.

Participating institutions include:

  • Cleveland Clinic
  • Florida State University
  • Johns Hopkins University
  • Mayo Clinic
  • Ohio State University
  • Penn State University
  • Pine Rest Christian Mental Health Services / Michigan State University
  • UC Davis
  • University of Cincinnati, Lindner Center of HOPE, and Cincinnati Children’s Hospital Medical Center
  • University of Colorado Anschutz Medical Campus
  • University of Iowa
  • University of Michigan
  • University of Texas at Austin Dell Medical School
  • University of Utah
  • UTHealth Houston
  • Western Michigan University, Homer Stryker M.D. School of Medicine and Van Andel Institute

Together, these organizations represent leading academic medical centers, health systems, specialty psychiatric programs, and research institutions committed to advancing measurement-based care and improving outcomes for individuals living with mood disorders.

An Expanding National Initiative

The Mood Outcomes Program continues to welcome new participating sites. While some centers are actively contributing data today, others are currently implementing workflows, integrating systems, or preparing their initial data submissions. As participation grows, so does the program’s ability to support quality improvement, benchmarking, collaborative research, and innovation in mood disorders care.

Measurement-Based Care

The Mood Outcomes Program uses the NNDC ePRO platform to collect standardized patient-reported outcomes before clinic visits.

Measures
  • PHQ-9 (Depression)
  • GAD-7 (Anxiety)
  • C-SSRS (Suicide Risk)

Participating centers use these data to improve patient care, support quality improvement initiatives, benchmark outcomes, and advance collaborative research.

Industry, Foundation, and Research Collaborations

The NNDC welcomes collaborations with industry, foundations, government agencies, health systems, and researchers who share our commitment to improving outcomes for individuals living with mood disorders.

Our Approach to Collaboration

The Mood Outcomes Program is designed to support clinically meaningful questions that can improve patient care, accelerate innovation, and advance scientific understanding.

Organizations interested in exploring treatment outcomes, care delivery models, implementation strategies, real-world evidence, health economics, or other research questions are encouraged to work collaboratively with NNDC and participating member centers.

Data Stewardship and Privacy
  • NNDC does not sell Mood Outcomes Program data.
  • NNDC does not provide unrestricted access to patient-level data.
  • NNDC does not transfer repository data to external organizations for independent use.

Instead, external collaborators work directly with NNDC leadership, the Johns Hopkins data repository team, and participating member centers to develop and answer important scientific and clinical questions.

Approved projects are conducted through established governance processes, with analyses performed under the oversight of NNDC and participating institutions. Findings and insights may be shared with collaborators, but the underlying repository data remain protected within the program’s governance framework.

This approach allows NNDC to support innovation and discovery while maintaining the highest standards of patient privacy, data security, and responsible stewardship.

Potential Areas for Collaboration
  • Real-world evidence studies
  • Treatment effectiveness analyses
  • Quality improvement initiatives
  • Measurement-based care implementation
  • Health economics and outcomes research
  • Clinical innovation and care delivery models
  • Mental health technology evaluation
  • Research supporting drug development and treatment pipelines
Data Management and Governance
Centralized Data Repository

Johns Hopkins University serves as the central repository and data coordinating center for the Mood Outcomes Program. The Johns Hopkins team works with participating NNDC member centers to:

  • Coordinate data collection activities
  • Maintain repository infrastructure
  • Ensure data quality and security
  • Support approved research and quality improvement projects
  • Fulfill approved data requests from NNDC members

This centralized approach allows participating centers to contribute to a shared resource while maintaining a strong commitment to patient privacy, data governance, and scientific rigor.

Scientific and Clinical Leadership

The Mood Outcomes Program is guided by a multidisciplinary steering committee composed of clinical, research, and administrative leaders from across the NNDC network.

Program Leadership

Peter Zandi, PhD (Johns Hopkins University) serves as the scientific lead for the Mood Outcomes Program and works closely with participating centers, NNDC leadership, and research collaborators to advance the program’s vision and research priorities.

David Katzelnick, MD (Mayo Clinic) serves as senior clinical advisor to the program, providing expertise in measurement-based care implementation and clinical quality improvement across participating sites.

Steering Committee
  • Carolyn Turvey, PhD, University of Iowa
  • David Katzelnick, MD, Mayo Clinic
  • Jeremy Kendrick, MD, University of Utah
  • J. Raymond DePaulo, Jr., MD, Johns Hopkins University
  • Matt Samocki, EdD, National Network of Depression Centers
  • Paresh Patel, MD, University of Michigan
  • Peter Zandi, PhD, Johns Hopkins University

The Steering Committee provides strategic oversight for the program, including data governance, member engagement, scientific priorities, quality improvement initiatives, and future program development.

Examples of Research Supported by the Mood Outcomes Program
Peer-Reviewed Publications
Scientific Presentations
Research Focus Areas

Mood Outcomes Program investigators continue to explore questions related to:

  • Depression and bipolar disorder outcomes
  • Suicide risk and prevention
  • Measurement-based care implementation
  • Quality improvement strategies
  • Real-world treatment effectiveness
  • Health services research
  • Population health
  • Longitudinal mood disorder outcomes

The publications and presentations listed above represent examples of scholarship supported by the Mood Outcomes Program and are not intended to be a comprehensive bibliography of all work generated through the program.

Questions or Interested in Learning More?

Whether you are an NNDC member center, healthcare organization, researcher, foundation, or industry partner, we welcome opportunities to discuss participation, collaboration, and future initiatives.

Contact: nndc@nndc.org

The National Network of Depression Centers (NNDC) was established in 2008 to mobilize collaborative expertise to counteract the public health crisis of depression, bipolar illnesses, and other mood disorders. The NNDC is a nonprofit network of academic medical centers dedicated to improving the lives of those affected by depression and related mood disorders. We are working to change the national conversation surrounding these illnesses through large-scale collaborative studies, education and outreach.

For questions, please email nndc@nndc.org

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If you are experiencing a suicidal, substance use, and/or mental health crisis, or any other kind of emotional distress, or if you are worried about someone who may need crisis support dial 988.

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