NNDC July 2014 Grant Alert

NNDC Grants and Publication Committee

Grant Alert July 2014

Ittleson Foundation

Objectives: Provide seed money for innovative pilot and model programs for projects that cut across the entire field and those that address underserved populations.
Opportunity for an NNDC task group or individual sites to seek funding for a pilot program. The NNDC will also be submitting a proposal to launch a new NNDC Visiting Professorship program.
Interest areas: all
Letter of Intent Deadline: 9/1/14 (see attachment)
Website: http://www.ittlesonfoundation.org


Consortium to Alleviate PTSD (CAP) RFA

Objectives: Significantly advance treatment strategies for PTSD; and Identify and confirm clinically relevant biomarkers
Opportunity for large cross site study
Interest areas: Military Veterans and Families / Biomarkers

Research activities must be focused on PTSD and common co-occurring psychiatric or medical conditions (see attachment)

Pre-proposal due: 8/14/14
Website:  www.ConsortiumToAlleviatePTSD.com (includes FAQs)

PCORI – Fall 2014 Cycle Opens August 6th


Assessment of Prevention, Diagnosis, and Treatment Options
Improving Healthcare Systems
Communication and Dissemination Research
Addressing Disparities
Improving Methods for Conducting Patient-Centered Outcomes Research

Opportunity for large cross-NNDC center collaboration
Deadline: Varies beginning 9/5/14 (see website below)
Website:  http://www.pcori.org/funding-opportunities/funding-announcements/upcoming-opportunities/
Notes: all Letters of Intent (LOI) will now be competitive, meaning they'll be reviewed for responsiveness and fit to program goals and only those researchers whose LOIs are selected will be invited to submit full applications.



The Grants and Publications Committee is available to support task group and cross-NNDC center proposals.  Dr. Michael Thase, University of Pennsylvania and Dr. Madhukar Trivedi, University of Texas Southwest chair the group and encourage you to bring forth ideas to pursue these or any other grant opportunities.  Please email Mary Simkins at msimkins@nndc.org to initiate the discussion.  Also, please forward any grant opportunities you would like to share with NNDC colleagues for distribution in future Grant Alerts.


Posted to on July 24, 2014


University of Louisville Depression Center News & Events

University of Louisville Depression Center


2013-2014 Public Relations Activities/Research/Articles:

2013 Annual Conference

Building Hope Community Presentation Series

2013 Special Event

Research Update

NNDC Task Groups

Website Update



2014 Annual Conference (CME/CEUs to be offered)


“Improving the Treatment of Mood and Anxiety Disorders”

November 13, 2014 – public presentation, The Clifton Center, Louisville, Kentucky, Donald Meichenbaum, PhD, Professor Emeritus, University of Waterloo, Ontario, Canada, “Bouncing Back: Six Keys to Psychological Strength”

November 14, 2014 – professional conference, The Clifton Center, Louisville, Kentucky

Keynote Speakers:

Jonathan E. Alpert, MD, Associate Chief and Clinical Director, Department of Psychiatry, Massachusetts General Hospital and Director, MGH Depression Clinical and Research Program
Donald Meichenbaum, PhD, Professor Emeritus, University of Waterloo, Ontario, Canada, and Research Director, Melissa Institute for Violence Prevention and Treatment of Victims of Violence, Miami, Florida
Joyce A. Spurgeon, MD, Associate Professor, Director, Residency Training Program, and Director, Women’s Mental Health Program, University of Louisville Department of Psychiatry & Behavioral Sciences

Additional faculty:

John E. Gallehr, MD, Assistant Professor, University of Louisville Department of Pediatrics, Division of Child and Adolescent Psychiatry
Amanda B. Hettinger, MD, Assistant Professor, University of Louisville Department of Psychiatry & Behavioral Sciences
Sarah Johnson, MD, MSc, Assistant Professor and Associate Director, Residency Training Program, University of Louisville Department of Psychiatry & Behavioral Sciences
Jonathan Weeks, MD, Assistant Professor, University of Louisville Department of Obstetrics, Gynecology and Women’s Health, Maternal-Fetal Medicine



“Advances in the Psychopharmacology of Depression: Stubborn Challenges, Promising Leads”
“The Context of a Woman’s Life:  Does It Affect the Treatment of Her Depression?”
“Roadmap to Resilience: Helping Patients Cope with Trauma”
“Better But Not Well:  On the Psychopharmacology of Residual Symptoms”
“Cognitive-behavioral Treatment Strategies for Individuals with PTSD and Prolonged and Complicated Grief”
“Treating Anxiety Disorders in Children and Adolescents”
“Well-being Therapy: From Symptom Relief to Personal Growth”
“Women and Substance Use Disorders: Update on Trends and Treatment Options”


Building Hope Community Presentation Series:


10/9/13                     “Coping with Bipolar Disorder: Eight Practical Strategies for Achieving Wellness”

                                    David Miklowitz, PhD, Professor of Psychiatry, UCLA Semel Institute


11/5/13                      “Aging Gracefully: Maintaining physical and mental health”

                                    David A. Casey, MD, Professor, UofL Department of Psychiatry & Behavioral Sciences


1/23/14                     “Breaking Through Procrastination: Unlock Your Potential”

                                    Jesse H. Wright, MD, PhD, Professor, UofL Dept of Psychiatry & Behavioral Sciences


2/6/14                       “Coping with Cancer: Mental health issues that patients and families experience”

                                    Rebecca Tamas, MD, Associate Professor, UofL Dept of Psychiatry & Behavioral Sciences


4/10/14                    “Understanding Obsessive-Compulsive Disorder: A Multitude of Distressing Thoughts

                                    and Rituals”

                                    Monnica Williams, PhD, Associate Professor, UofL Department of Psychological and

                                    Brain Sciences


2014-2015 (Dates TBD)

09/14                        “Alzheimer’s Disease/Dementia – Q&A”

                                    David A. Casey, MD, Professor, UofL Dept of Psychiatry & Behavioral Sciences


10/14                         “About Autism”

                                    David Lohr, MD, Associate Professor, UofL Dept of Pediatrics, Division of Child and

                                    Adolescent Psychiatry


11/13/14                    “Bouncing Back:  Six Keys to Psychological Strength” (Public Presentation as part of annual

                                    Depression and Mood Disorders Conference)

                                    Don Meichenbaum, PhD, Research Director, Melissa Institute for Violence Prevention

                                    and Treatment of Victims of Violence, Miami, FL


01/15                         “Social Media”

                                    Robert Caudill, MD, Associate Professor, UofL Dept of Psychiatry & Behavioral Sciences


02/15                         “Gaming: Good, Bad, & the Ugly”

                                    Chris Peters, MD, Associate Professor, and John McCurdy, MD, UofL Dept of Pediatrics,

                                    Division of Child and Adolescent Psychiatry


03/15                         “Stress Management”

                                    Eric Russ, PhD, Assistant Professor, UofL Dept of Psychiatry & Behavioral Sciences


04/15                        “Addictions”

                                    Erika Ruth, MD, Assistant Professor, and Suzanne Franki, MD, Assistant Professor, UofL

                                    Dept of Psychiatry & Behavioral Sciences



The 2014-2015 Building Hope Community Presentation Series will be developed soon for the 2014-2015 academic year.


Special Events:



Guest Speaker:  Thomas Styron, PhD, Associate Professor of Psychiatry at Yale University, and son of Pulitzer Prize winning novelist William Styron, author of Darkness Visible and Sophie’s Choice.  Dr. Styron shared his experiences of his father’s struggle with depression.



Guest Speaker:  Eric Hipple, former quarterback for the Detroit Lions, and author of the book, “Real Men do cry” will speak at a special event to benefit the UofL Depression Center.  He will deliver a powerful message about his struggle with depression and a near-lethal suicide attempt.




Funding Approved:

Disease Management Program funded by University of Louisville; Clinical Director, Eric Russ, PhD – will include assessments for depression, online tracking of outcomes, use of “best practices” guidelines, educational activities, and case management.  A nurse practitioner will be hired to provide urgent care for UofL employees diagnosed with mood disorders


Funding Pending:

Dissemination of Computer-assisted Cognitive-Behavior Therapy in Primary Care; NIH 1R18HS023482-01
Event-Related-Potential (ERP) and Gamma-band EEG as an Outcome Measure in the Prefrontal Gamma Neurofeedback-based Treatment of Depression


Other ongoing studies include: 

Computer-assisted Cognitive-behavior Therapy for Depression; NIH/NIMH R01MH082762
Kentucky National Guard Program for PTSD
Cognitive Therapy for Depressive Symptoms in Hospitalized Patients with Heart Failure; NIH/NINR K23NR013480 (in collaboration with University of Kentucky)


Newly funded programs include:

Genetic testing study focused on improving outcomes of pharmacotherapy of depression – Impact of GeneSight Psychotropic Genetic Testing on Response to Psychotropic Treatment in Major Depressive Disorder.  This project is being performed at multiple sites of the National Network of Depression Centers.  Dr. Rif El-Mallakh will lead this investigation at the UofL
Collaborative effort with the UofL School of Nursing and the Depression Center to treat depression in mothers of children with severe mental illnesses – Social Media, Teen Moms and Postpartum Depression (PPD); NIH/NINR
Collaborative study with Boston University and the Depression Center on learning enhancement in computerized therapy with d-cycloserine – Improving Therapeutic Learning in Depression:  Proof of Content
Collaborative effort with the UofL School of Nursing and the Depression Center – Improving Outcomes for Children with Special Needs and Their Caregivers Using CBT


NNDC Clinical Care Registry:

A total of 57 patients are currently participating in the registry



NNDC Task Groups/Faculty Assigned:

David A. Casey, MD, Professor and Senior Vice-Chair, Head of Clinical Services, Department of Psychiatry and Behavioral Sciences

                  ¤ Clinical Care Registry Implementation Group

                  ¤ Geriatric Mood Disorders Task Group

                  ¤ ECT Task Group


Robert Caudill, MD, Associate Professor, Director, Telemedicine/Information Technology Programs, Department of Psychiatry and Behavioral Sciences

                  ¤ Telehealth Task Group


Rif El-Mallakh, MD, Professor and Director, Mood Disorders Clinical and Research Program, Department of Psychiatry and Behavioral Sciences

                  ¤ Bipolar Disorder Task Group

                  ¤ Implementation & Dissemination Task Group


Joyce Spurgeon, MD, Associate Professor and Director, Residency Training and Women’s Mental Health Programs, Department of Psychiatry and Behavioral Sciences

                  ¤ Mood Disorders in Women Task Group


Allan Tasman, MD, Professor and Chair, Department of Psychiatry and Behavioral Sciences

                  ¤ NNDC Executive Committee

                  ¤ NNDC Board of Directors


Jesse H. Wright, MD, PhD, Professor and Vice-Chair for Academic Affairs, Director, UofL Depression Center, Department of Psychiatry and Behavioral Sciences

                  ¤ NNDC Board of Directors

                  ¤ rTMS Task Group




UofL Depression Center website:


UofL Depression Center website was recently updated.  Dr. Wright is currently sending out “tweets” on various subjects related to mental health – he invited everyone to connect with his account, jesswrightmd.  Kate Spurling, LCSW, volunteered to help set up and maintain the link between the Depression Center facebook and twitter accounts and also connect Dr. Wright’s twitter account. UofL Depression Center website address:  www.louisville.edu/depression




Allan Tasman, MD

Recipient, President’s Distinguished Faculty Award for National/International Service, University of Louisville, 2013
Recipient, Honorio Delgado Visiting Professor, Universidad Cayetano Peruana School of Medicine, Lima, Peru, 2014
Business First Partners in Health Care Award, Business First, 2013, 2014


Jesse H. Wright, MD, PhD

Recipient, Aaron T. Beck Institute for Cognitive Studies Award for Excellence, Assumption College, Worcester, Massachusetts, May 30, 2014


Communications/Public Relations Contacts:

Jill Scoggins – Associate Director of Communications, University of Louisville, Health Sciences Campus

Email:  jill.scoggins@louisville.edu

Jill works with us to promote/advertise our academic and community events, including the Building Hope Community Presentations, annual conference, special events, etc.


Diane Partridge – Vice-President of Marketing and Communications, University of Louisville Physicians

Email:  diane.partridge@ulp.org

Website:  www.uoflphysicians.com

Diane and her staff work with us to promote the clinical practice, including all of our services – comprehensive evaluation and treatment, bipolar disorder treatment, CBT and other therapies, Women’s Mental Health Program, chemical dependency treatment, student mental health, TMS, and Virtual Reality treatment.


Posted to on July 24, 2014


Why Teenagers Act Crazy

A recent New York Times article featuring NNDC member Richard A. Friedman explored the neurological causes behind teenage anxiety and depression.

ADOLESCENCE is practically synonymous in our culture with risk taking, emotional drama and all forms of outlandish behavior. Until very recently, the widely accepted explanation for adolescent angst has been psychological. Developmentally, teenagers face a number of social and emotional challenges, like starting to separate from their parents, getting accepted into a peer group and figuring out who they really are. It doesn’t take a psychoanalyst to realize that these are anxiety-provoking transitions.

But there is a darker side to adolescence that, until now, was poorly understood: a surge during teenage years in anxiety and fearfulness. Largely because of a quirk of brain development, adolescents, on average, experience more anxiety and fear and have a harder time learning how not to be afraid than either children or adults.

Different regions and circuits of the brain mature at very different rates. It turns out that the brain circuit for processing fear — the amygdala — is precocious and develops way ahead of the prefrontal cortex, the seat of reasoning and executive control. This means that adolescents have a brain that is wired with an enhanced capacity for fear and anxiety, but is relatively underdeveloped when it comes to calm reasoning.

Continue reading the full article here.

Richard A. Friedman is a professor of clinical psychiatry and the director of the psychopharmacology clinic at the Weill Cornell Medical College.


Posted to on July 24, 2014


2014 Conference Poster Submission Guidelines

NNDC 2014 Conference

Poster Session Invitations, Overview, Guidelines and Awards

The NNDC Annual Conference will be held in Chicago October 23-24 at the University of Illinois Chicago and the Palmer House Hotel.  Poster presentations are strongly encouraged.  All conference attendees are invited to submit a poster related to depressions and bipolar illnesses, focusing on our theme of “DEPRESSIONS AND BIPOLAR ILLNESSES: ACCELERATING DISSEMINATION OF INNOVATIONS.” 

  1. A select subset of approximately 40 posters will be displayed at the University of Illinois at Chicago on October 23-24, 2014. Posters should be hung by 9:00 AM on Thursday the 23rd, and taken down at noon on Friday October 24th.
  2. Posters should be 36 inches high X 48 inches wide, and will be fastened to cork boards.
  3. Prizes will be awarded in 3 categories. A review committee will determine awardees, and a $250 prize will be given to the winning posters (one award per poster, with allocations to be determined by the authors):
  • Innovation - Novel concepts that show promise/progress toward development of biomarkers, new or repurposed treatments, or monitoring strategies.
  • Dissemination - Many innovations lead to publications; too few innovations or publications lead to meaningful improvements in diagnosis, biomarkers, personalized treatments, and dissemination to targeted and global populations.
  • Resident, Post-Doctoral or Trainee Award - An award allocation to the primary author of a poster who has not yet completed formal training and is not yet a faculty member.  This award is intended to encourage emerging scholarship at an early level.

Posters will be available to view online beginning October 19th.  Review Committee members can vote online or in person at the conference from October 19 through noon on October 23. Posters will remain online until October 31 to allow the greatest number of people to view them.


August 30 – Abstracts may be submitted as early as July 1, and will be accepted through August 30. Abstracts must be kept to ½ page or less, and sent to jdejesus@nndc.org by 5:00 PM August 30, 2014. Abstract presentation acceptance will be based upon Program Committee review, and the first 40 accepted posters will be presented in physical format. Additional posters may be accepted beyond the first 40, but will only be displayed in electronic format (online, and in a background presentation at the reception/dinner).
September 30 – Submit the final electronic version of your poster to jdejesus@nndc.org
October 23 – Hang your poster by 9:00 AM at the University of Illinois at Chicago Student Center West.
October 24 – Take posters down by 12:00 PM. Posters will not be returned if left behind at the conference.



Posted to Annual ConferenceEvents on June 25, 2014


Mayo Clinic - Translational Bridges in Mood and Addiction CME Event

Mayo Clinic Presents

Translational Bridges in Mood & Addiction: Bench to Bedside & Back to Bench

September 4-6, 2014 at the Double Tree Hotel in Rochester, MN

Course Directors: Doo-Sup Choi, PhD, Mark A. Frye, MD, and Susannah J. Tye, PhD

poster scholarship is available to two clinicians, which will include travel, hotel, and registration.

Visit this link for the Event Page, click here to view the Course Agenda, and select this link for Credit Information.


Posted to on May 27, 2014


President Obama's Focus for May: Mental Health Awareness and Treatment

"Despite great strides in our understanding of mental illness and vast improvements in the dialogue surrounding it, too many still suffer in silence," President Barack Obama states in his April 30th proclamation. In proclaiming May 2014 as National Mental Health Awareness Month, President Obama seeks to rally the country in "reaffirm[ing] our commitment to building our understanding of mental illness, increasing access to treatment, and ensuring those who are strugglign to know they are not alone."

The NNDC is encouraged by the president's vocal support of mental health awareness campaigns, as well as his effort to make mental health care as accessible as other forms of medical treatment. The NNDC agrees with the statement that we, as a society, "too often think about mental health differently from other forms of health. Yet like any disease, mental illnesses can be treated - and without help, they grow worse."

If you are wondering what you can do to participate in mental health awareness month, here are some steps you can take:

  • If you are a sufferer of depression or another mood disorder and haven't yet sought treatment, now is the time to take the first step. Click here to learn more about treatment referrals by state.
  • If you know someone who may be suffering from an "invisible illness," show them support this month by doing your part to combat stigma.
  • If you would like to support mental health research, make a donation to the National Network of Depression Centers by following this link.

You can read the full text of President Obama's proclamation here.


Posted to on May 02, 2014


2014 NNDC Annual Conference

NNDC 2014 Annual Conference - University of Illinois at Chicago

October 22 - 24, 2014

"Depressions and Bipolar Illnesses: Accelerating Dissemination of Innovations"
Keynote Speaker - Thomas R. Insel, MD, Director of the NIMH

Overview of Events
October 22nd - Executive Committee Meeting, Board Meeting, and Welcome Reception- Palmer House Hilton

October 23rd - Scientific Meeting - University of Illinois at Chicago, Dinner - Palmer House

October 24th - Scientific Meeting (1/2 Day Program)

Book a Room in the NNDC Room Block
REGISTER for the Conference
View the Agenda

All conference attendees are invited to submit posters. View the Poster Submission Information here.

Accreditation Statement:
This activity is jointly sponsored by University of Illinois College of Medicine at Chicago and the National Network of  Depression Centers.

This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accredita tion  Council for Continuing Medical Education (ACCME) through the joint sponsorship of the University of Illinois College of Medicine at Chicago and the National Network of Depression Centers.  The University of Illinois College of Medicine at  Chicago is accredited by the ACCME to provide continuing medical education for physicians. 

The University of Illinois College of Medicine at Chicago designates this Live Activity for a maximum of 9.5 AMA PRA  Category 1 Credit(s)TM.  Physicians should claim only the credit commensurate with the extent of their participation in the activity. 

We hope you will join us for this exciting event!


Posted to Annual ConferenceEvents on April 23, 2014


Check out our archived newsletters to see what the NNDC has been up to in 2014!


Posted to on April 03, 2014


First stem cell study of bipolar disorder yields promising results

Haiming Chen, M.D., and Cindy DeLong, Ph.D.

Stem cell model shows nerve cells develop, behave and respond to lithium differently – opening doors to potential new treatments.

Read the news article here


Posted to Members in the News & Publications on March 26, 2014


Transcripts involved in calcium signaling and telencephalic neuronal fate

H M Chen, C J DeLong, M Bame, I Rajapakse, T J Herron, M G McInnis, and K S O’Shea

Bipolar disorder (BP) is a chronic psychiatric condition characterized by dynamic, pathological mood fluctuations from mania to depression. To date, a major challenge in studying human neuropsychiatric conditions such as BP has been limited access to viable central nervous system tissue to examine disease progression. Patient-derived induced pluripotent stem cells (iPSCs) now offer an opportunity to analyze the full compliment of neural tissues and the prospect of identifying novel disease mechanisms. We have examined changes in gene expression as iPSC derived from well-characterized patients differentiate into neurons; there was little difference in the transcriptome of iPSC, but BP neurons were significantly different than controls in their transcriptional profile. Expression of transcripts for membrane bound receptors and ion channels was significantly increased in BP-derived neurons compared with controls, and we found that lithium pretreatment of BP neurons significantly altered their calcium transient and wave amplitude. The expression of transcription factors involved in the specification of telencephalic neuronal identity was also altered. Control neurons expressed transcripts that confer dorsal telencephalic fate, whereas BP neurons expressed genes involved in the differentiation of ventral (medial ganglionic eminence) regions. Cells were responsive to dorsal/ventral patterning cues, as addition of the Hedgehog (ventral) pathway activator purmorphamine or a dorsalizing agent (lithium) stimulated expression of NKX2-1 (ventral identity) or EMX2 (dorsal) in both groups. Cell-based models should have a significant impact on our understanding of the genesis and therefore treatment of BP; the iPSC cell lines themselves provide an important resource for comparison with other neurodevelopmental disorders.


calcium signaling; disease modeling; microarray analysis; neuronal differentiation

Link to the Publication


Posted to Members in the News & Publications on March 26, 2014


Care For Your Mind

In a recent interview with Care For Your Mind, Dr. Greden talks about the collaborative efforts of the NNDC. Care For Your Mind is a website that provides exposure to a diverse group of perspectives on mental health solutions, policy, and reform, as they relate to mental health care in America.

Read Part I

Read Part II


Posted to Events on March 25, 2014